Pathophysiology of ANCA-associated vasculitis: are ANCA really pathogenic? A note of caution.
نویسندگان
چکیده
1. MANJUNATH G, SARNAK MJ, LEVEY AS: Prediction equations to estimate glomerular filtration rate: An update. Curr Opin Nephrol Hypertens 10:785–792, 2001 2. NATIONAL KIDNEY FOUNDATION: K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis 39(Suppl 1):S1–266, 2002 3. KEITH DS, NICHOLS GA, GULLION CM, et al: Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch Intern Med 164:659–663, 2004
منابع مشابه
Pathophysiology of ANCA-associated vasculitides: are ANCA really pathogenic?
The strong relation between antineutrophil cytoplasmic autoantibodies (ANCA) and primary vasculitic syndromes suggests a pathophysiological role for ANCA. Experimental evidence for the pathogenic potential of ANCA has been derived from in vitro studies that demonstrate that ANCA can activate tumour necrosis factor alpha primed neutrophils, monocytes and/or endothelial cells. The binding of ANCA...
متن کاملDifferentiation of Cocaine-Induced Midline Destructive Lesions from ANCA-Associated Vasculitis
Introduction: Cocaine-induced midline destructive lesions (CIMDL) are complications of regular nasal cocaine inhalation. CIMDL can mimic systemic diseases with positive anti-neutrophil cytoplasmic antibodies (ANCA), such as granulomatosis with polyangiitis (GPA). Case Report: In this article, we describe the case of a young woman who presented with nasal perforation induced by cocaine, al...
متن کاملInfective endocarditis mimics ANCA associated glomerulonephritis
Background: Sub-acute bacterial endocarditis (SBE) rarely presents with features of a small vessel vasculitis. Patients with SBE can also develop multiple serological abnormalities including ANCA. In this report, we present a case of infective endocarditis mimicked ANCA associated glomerulonephritis.Case presentation: A 57-year old male with a clinical picture of rapidly progressive renal failu...
متن کاملMechanisms of vasculitis: how pauci-immune is ANCA-associated renal vasculitis?
Both the innate and the acquired immune system are involved in the pathophysiology of renal vasculitis. However, anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis is characterized by a 'pauci-immune' pattern of immunofluorescence during kidney biopsy, indicating the relative lack of immunoglobulin and complement deposition within the kidney. On the other hand, evidence is ...
متن کاملPathophysiology of ANCA-Associated Small Vessel Vasculitis
Antineutrophil cytoplasmic autoantibodies (ANCAs) directed to proteinase 3 (PR3-ANCA) or myeloperoxidase (MPO-ANCA) are strongly associated with the ANCA-associated vasculitides--Wegener's granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome. Clinical observations, including the efficacy of B-cell depletion via rituximab treatment, support--but do not prove--a pathogenic role fo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Kidney international
دوره 66 5 شماره
صفحات -
تاریخ انتشار 2004